IL-6 Promotes NK Cell Production of IL-17 during Toxoplasmosis

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IL-6 promotes NK cell production of IL-17 during toxoplasmosis.

Previous studies have implicated T cell production of IL-17 in resistance to Toxoplasma gondii as well as the development of immune-mediated pathology during this infection. Analysis of C57BL/6 and C57BL/6 RAG(-/-) mice challenged with T. gondii-identified NK cells as a major innate source of IL-17. The ability of soluble Toxoplasma Ag to stimulate NK cells to produce IL-17 was dependent on the...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2010

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.0901843